{
    "$schema": "https://tipsforacne.com/data/schema/aad-2024-recommendations.schema.json",
    "name": "AAD 2024 Acne Guideline Dataset: 18 Graded Recommendations and 5 Good Practice Statements",
    "license": "CC BY 4.0 — attribute TipsForAcne and link to https://tipsforacne.com/data/aad-2024-recommendations/",
    "source": "https://pubmed.ncbi.nlm.nih.gov/38300170/",
    "checked": "2026-09-24",
    "field_definitions": {
        "number": "Recommendation number as given in the guideline.",
        "recommendation": "The recommendation or good practice statement, in short form.",
        "type": "Graded recommendation or Good practice statement.",
        "strength": "Strength of the recommendation. Meanings in strength_definitions.",
        "certainty": "GRADE certainty of the evidence. 'Not graded' for good practice statements. Meanings in certainty_definitions."
    },
    "strength_definitions": {
        "Strong": "Recommended: benefits clearly outweigh harms for most patients.",
        "Conditional": "Suggested: the benefit-harm balance is closer, so the choice depends on the patient's circumstances and preferences.",
        "Conditional against": "Suggested against.",
        "Ungraded": "Good practice statement; no strength is assigned."
    },
    "certainty_definitions": {
        "High": "Very confident that the true effect is close to the estimate.",
        "Moderate": "Moderately confident: the true effect is probably close to the estimate, but could be substantially different.",
        "Low": "Limited confidence: the true effect may be substantially different from the estimate.",
        "Very low": "Very little confidence: the true effect is likely to be substantially different from the estimate.",
        "Not graded": "Good practice statement; certainty is not graded."
    },
    "definitions_sources": [
        "Reynolds RV et al. Guidelines of care for the management of acne vulgaris. J Am Acad Dermatol. 2024. https://pubmed.ncbi.nlm.nih.gov/38300170/",
        "GRADE Working Group. Balshem H et al. GRADE guidelines: 3. Rating the quality of evidence. J Clin Epidemiol. 2011;64(4):401-406. https://pubmed.ncbi.nlm.nih.gov/21208779/"
    ],
    "records": 23,
    "statements": [
        {
            "number": "1.2",
            "recommendation": "Benzoyl peroxide",
            "type": "Graded recommendation",
            "strength": "Strong",
            "certainty": "Moderate"
        },
        {
            "number": "1.3",
            "recommendation": "Topical retinoids",
            "type": "Graded recommendation",
            "strength": "Strong",
            "certainty": "Moderate"
        },
        {
            "number": "1.4",
            "recommendation": "Topical antibiotics",
            "type": "Graded recommendation",
            "strength": "Strong",
            "certainty": "Moderate"
        },
        {
            "number": "1.5",
            "recommendation": "Clascoterone",
            "type": "Graded recommendation",
            "strength": "Conditional",
            "certainty": "High"
        },
        {
            "number": "1.6",
            "recommendation": "Salicylic acid",
            "type": "Graded recommendation",
            "strength": "Conditional",
            "certainty": "Low"
        },
        {
            "number": "1.7",
            "recommendation": "Azelaic acid",
            "type": "Graded recommendation",
            "strength": "Conditional",
            "certainty": "Moderate"
        },
        {
            "number": "1.8",
            "recommendation": "Fixed-dose topical antibiotic + benzoyl peroxide",
            "type": "Graded recommendation",
            "strength": "Strong",
            "certainty": "Moderate"
        },
        {
            "number": "1.9",
            "recommendation": "Fixed-dose topical retinoid + antibiotic",
            "type": "Graded recommendation",
            "strength": "Strong",
            "certainty": "Moderate"
        },
        {
            "number": "1.10",
            "recommendation": "Fixed-dose topical retinoid + benzoyl peroxide",
            "type": "Graded recommendation",
            "strength": "Strong",
            "certainty": "Moderate"
        },
        {
            "number": "2.1",
            "recommendation": "Doxycycline (systemic)",
            "type": "Graded recommendation",
            "strength": "Strong",
            "certainty": "Moderate"
        },
        {
            "number": "2.2",
            "recommendation": "Minocycline (systemic)",
            "type": "Graded recommendation",
            "strength": "Conditional",
            "certainty": "Moderate"
        },
        {
            "number": "2.3",
            "recommendation": "Sarecycline (systemic)",
            "type": "Graded recommendation",
            "strength": "Conditional",
            "certainty": "High"
        },
        {
            "number": "2.4",
            "recommendation": "Doxycycline in preference to azithromycin",
            "type": "Graded recommendation",
            "strength": "Conditional",
            "certainty": "Low"
        },
        {
            "number": "3.1",
            "recommendation": "Combined oral contraceptive pills",
            "type": "Graded recommendation",
            "strength": "Conditional",
            "certainty": "Moderate"
        },
        {
            "number": "3.2",
            "recommendation": "Spironolactone",
            "type": "Graded recommendation",
            "strength": "Conditional",
            "certainty": "Moderate"
        },
        {
            "number": "4.2",
            "recommendation": "Traditional daily isotretinoin over intermittent dosing",
            "type": "Graded recommendation",
            "strength": "Conditional",
            "certainty": "Low"
        },
        {
            "number": "4.3",
            "recommendation": "Standard or lidose isotretinoin (equivalent options)",
            "type": "Graded recommendation",
            "strength": "Conditional",
            "certainty": "High"
        },
        {
            "number": "5.1",
            "recommendation": "Pneumatic broadband light added to adapalene 0.3% gel",
            "type": "Graded recommendation",
            "strength": "Conditional against",
            "certainty": "Low"
        },
        {
            "number": "1.1",
            "recommendation": "Multimodal topical therapy, combining mechanisms of action",
            "type": "Good practice statement",
            "strength": "Ungraded",
            "certainty": "Not graded"
        },
        {
            "number": "2.5",
            "recommendation": "Limiting the duration of systemic antibiotic use",
            "type": "Good practice statement",
            "strength": "Ungraded",
            "certainty": "Not graded"
        },
        {
            "number": "2.6",
            "recommendation": "Concomitant benzoyl peroxide with systemic antibiotics",
            "type": "Good practice statement",
            "strength": "Ungraded",
            "certainty": "Not graded"
        },
        {
            "number": "3.3",
            "recommendation": "Intralesional corticosteroid injection for individual lesions",
            "type": "Good practice statement",
            "strength": "Ungraded",
            "certainty": "Not graded"
        },
        {
            "number": "4.1",
            "recommendation": "Isotretinoin for severe acne",
            "type": "Good practice statement",
            "strength": "Ungraded",
            "certainty": "Not graded"
        }
    ],
    "url": "https://tipsforacne.com/data/aad-2024-recommendations/",
    "json_url": "https://tipsforacne.com/data/aad-2024-recommendations.json",
    "generated": "2026-09-25T22:51:14+00:00",
    "publisher": {
        "name": "TipsForAcne",
        "url": "https://tipsforacne.com/"
    },
    "disclaimer": "Informational dataset published by TipsForAcne (tipsforacne.com), an independent research site. Not medical advice; see a dermatologist for treatment decisions."
}